Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon
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چکیده
منابع مشابه
Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and antinociceptive effects in rodents at low doses.
In the present study, we evaluated omega-3 polyunsaturated fatty acid (PUFA) (consisting of 20:5n-3 and 22:6n-3) properties on inflammation and nociception. Among the in vivo tests, writhing, formalin, and hot plate tests were conducted in mice, and carrageenan-induced paw edema, peritonitis, and Hargreaves tests were performed in rats. Following the carrageenan-induced edema, immunohistochemis...
متن کاملEvaluation of linoleic acid, eladic acid and palmitic acid for cytotoxicity and anti-inflammatory activities
Background and objectives: Nigella sativa seeds have shown to possess anti-inflammatory, anti-oxidant, trenquillizer, chemopreventive and anti-neoplastic effects. Besides, they areused as nutritional flavoring agents. We have investigated the protective effects of N. sativa seeds hexane extract and active principles against methyl phenyl pyridine (MP...
متن کاملPreparation of ursodeoxycholic acid from 7-ketone lithocholic acid by stereoselective electroreduction
Background: Ursodeoxycholic acid (UDCA) is an important clinical drug in the treatment of liver disease. In previous work, ursodeoxycholic acid was prepared by traditional organic synthesis. The preparation of ursodeoxycholic acid through an electrochemical method with higher stereoselectivity and environmental friendliness is described herein. Results: Dimethyl sulfoxide (DMSO), dimethylformam...
متن کاملAnti-inflammatory effects of ursodeoxycholic acid by lipopolysaccharide-stimulated inflammatory responses in RAW 264.7 macrophages
PURPOSE The aim of this study was to investigate the anti-inflammatory effects of Ursodeoxycholic acid (UDCA) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. METHODS We induced an inflammatory process in RAW 264.7 macrophages using LPS. The anti-inflammatory effects of UDCA on LPS-stimulated RAW 264.7 macrophages were analyzed using nitric oxide (NO). Pro-inflammatory and anti-i...
متن کاملUrsodeoxycholic acid
Ursodeoxycholic acid is an epimer of chenodeoxycholic acid (DB06777). It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic. [PubChem] Indication: The drug reduces cholesterol absorption and is used to dis...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology
سال: 2017
ISSN: 0193-1857,1522-1547
DOI: 10.1152/ajpgi.00256.2016